Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear
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چکیده
منابع مشابه
Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear.
Each of the sensory patches in the epithelium of the inner ear is a mosaic of hair cells and supporting cells. Notch signalling is thought to govern this pattern of differentiation through lateral inhibition. Recent experiments in the chick suggest, however, that Notch signalling also has a prior function - inductive rather than inhibitory - in defining the prosensory patches from which the dif...
متن کاملExpression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear
The Notch signalling pathway is thought to play a key part in controlling the production of sensory hair cells in the vertebrate inner ear via lateral inhibition; but there is disagreement as to which Notch ligands are expressed in hair cells as they develop. We show, using a mouse Delta1:LacZ knock-in as a reporter, that nascent hair cells, but not their neighbours, express Delta1. Expression ...
متن کاملThe Notch ligand Jagged1 is required for inner ear sensory development.
Within the mammalian inner ear there are six separate sensory regions that subserve the functions of hearing and balance, although how these sensory regions become specified remains unknown. Each sensory region is populated by two cell types, the mechanosensory hair cell and the supporting cell, which are arranged in a mosaic in which each hair cell is surrounded by supporting cells. The propos...
متن کاملDistinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear
The cochlea and vestibular structures of the inner ear labyrinth develop from the otic capsule via step-wise regional and cell fate specification. Each inner ear structure contains a sensory epithelium, composed of hair cells, the mechanosensory transducers, and supporting cells. We examined the spatio-temporal expression of genes in the Notch signaling pathway, Notch receptors (Notch1-4) and t...
متن کاملThe Role of Notch Ligands in Development of the Inner Ear
The sensory epithelium of the inner ear consists of a mosaic pattern of hair cells separated from one another by supporting cells. The Notch signalling pathway is thought to establish this pattern through a process of lateral inhibition, and has recently been shown to have an early role in inducing sensory patch formation. Several Notch ligands are expressed in the developing sensory patch, but...
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ژورنال
عنوان ژورنال: Development
سال: 2006
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.02284